Drug delivery

P.L.E.A.S.E.® is a multi-application platform based on Pantec Biosolutions’ proprietary diode-pumped laser technology.

Pantec Biosolutions developed a novel platform for  transdermal delivery of large molecule drugs. Although transdermal application of drugs is a very powerful administration route, there are still very few patches on the market.  The reason for this is that only a few molecules are able to pass the outer skin layers passively to finally reach the blood capillaries in the dermis. The outermost layer, the stratum corneum in particular, provides a strong barrier for molecules larger than 500 Dalton. So pretreating skin with microporation is a route to effect successful transdermal delivery of larger proteins and any other drug molecule.


Pantec Biosolutions' proprietary laser- powered P.L.E.A.S.E.® extends the range of drugs that can be delivered transdermally. This novel application allows both low and high molecular weight drugs to be delivered directly into the various layers of the skin.


In collaboration with leading patch development and manufacturing companies, Pantec Biosolutions has developed a skin patch technology for use with P.L.E.A.S.E.® in the delivery of large molecule proteins used for In Vitro Fertilisation (IVF) and other applications.

P.L.E.A.S.E.® is the method of choice for the transdermal application of infertility hormones and other large molecular weight drugs due to the following:

  • Simple and convenient to use by patients and health professionals
  • Precise, painless and reliable, regardless of the patient's skin condition
  • Allows control of the drug dose by variation of pores while drug permeation can be stopped by simply removing the patch
  • Delivers more and higher molecular weight drugs
  • Deposits drugs precisely into selected layers of the skin

These links may be interesting for you:

P.L.E.A.S.E.® Devices